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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 728892
Species: Rattus norvegicus
RGD Object: Gene
Symbol: E2f1
Name: E2F transcription factor 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
E2f1affects activityISOE2F1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the activity of E2F1 proteinPMID:20624995
E2f1decreases expressionISOE2F1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of E2F1 mRNA; Benzo(a)pyrene results in decreased expression of E2F1 proteinPMID:20064835 PMID:21802500
E2f1increases expressionISOE2F1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of E2F1 mRNA; Benzo(a)pyrene results in increased expression of E2F1 proteinPMID:16406622 PMID:32234424
E2f1increases methylationISOE2F1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of E2F1 promoterPMID:27901495
E2f1multiple interactionsISOE2F1 (Homo sapiens)6480464CTDCCND1 protein promotes the reaction [Benzo(a)pyrene results in increased expression of E2F1 protein]; CDK4 protein promotes the reaction [Benzo(a)pyrene results in increased expression of E2F1 protein]; Tretinoin inhibits the reaction [Benzo(a)pyrene results in increased expression of E2F1 protein]PMID:16406622
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