GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp27a1 | multiple interactions | EXP | | 6480464 | CTD | [CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol | PMID:8496670 | Cyp27a1 | increases abundance | ISO | CYP27A1 (Homo sapiens) | 6480464 | CTD | CYP27A1 protein results in increased abundance of 27-hydroxycholesterol | PMID:12119285 | Cyp27a1 | increases chemical synthesis | ISO | CYP27A1 (Homo sapiens) | 6480464 | CTD | CYP27A1 protein results in increased chemical synthesis of 27-hydroxycholesterol | PMID:11714861 PMID:12531903 PMID:14622972 | Cyp27a1 | multiple interactions | ISO | CYP27A1 (Homo sapiens) | 6480464 | CTD | [[CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol] which results in increased activity of HMGCR protein; [CYP27A1 protein results in increased hydroxylation of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol; [CYP27A1 protein results in increased metabolism of Cholesterol] which results in increased chemical synthesis of 27-hydroxycholesterol; [CYP27A1 protein results in increased oxidation of 27-hydroxycholesterol] which results in increased chemical synthesis of 3-hydroxy-5-cholestenoic acid; [TGFB1 protein results in increased expression of CYP27A1 protein] which results in increased abundance of 27-hydroxycholesterol | PMID:11408283 PMID:15708352 PMID:9215552 PMID:9660774 | | ||||||||||||||||||||||
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