Gene Chemical Interaction Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	727889
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Rela
Name:	RELA proto-oncogene, NF-kB subunit

Acc ID:	CHEBI:53556
Term:	toluene 2,4-diisocyanate
Definition:	A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring.
Chemical ID:	MESH:D014051

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Rela	increases expression	ISO	Rela (Mus musculus)	6480464	CTD	Toluene 2,4-Diisocyanate results in increased expression of RELA protein	PMID:17982072
Rela	increases localization	ISO	Rela (Mus musculus)	6480464	CTD	Toluene 2,4-Diisocyanate results in increased localization of RELA protein	PMID:17015710
Rela	multiple interactions	ISO	Rela (Mus musculus)	6480464	CTD	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein]; Pioglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased localization of RELA protein]; PPARG protein affects the reaction [Toluene 2,4-Diisocyanate results in increased localization of RELA protein]; PTEN protein inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein]; Rosiglitazone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased localization of RELA protein]; Wortmannin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein]	PMID:17015710 PMID:17982072

Go Back to source page

Continue to Ontology report