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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:5001
Term: fenofibrate
Definition: A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring.
Chemical ID: MESH:D011345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relamultiple interactionsEXP 6480464CTD[Fenofibrate co-treated with Sodium Glutamate] results in increased expression of RELA protein; Fenofibrate inhibits the reaction [Dietary Fats results in increased expression of RELA protein]; Fenofibrate inhibits the reaction [Doxorubicin results in increased expression of RELA protein]; Fenofibrate promotes the reaction [Pioglitazone inhibits the reaction [Doxorubicin results in increased expression of RELA protein]]; Pioglitazone promotes the reaction [Fenofibrate inhibits the reaction [Doxorubicin results in increased expression of RELA protein]]PMID:21999347 PMID:36988379 PMID:38216941
Relamultiple interactionsISORELA (Homo sapiens)6480464CTDFenofibrate affects the localization of and results in decreased activity of RELA protein; Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of RELA protein]; Fenofibrate inhibits the reaction [Glucose results in increased expression of RELA protein]; Fenofibrate results in decreased localization of and results in decreased activity of RELA proteinPMID:16600694 PMID:20520642 PMID:20580385 PMID:25545733
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