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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Reladecreases expressionEXP 6480464CTDChlorpyrifos results in decreased expression of RELA mRNAPMID:30621213
Relaincreases expressionEXP 6480464CTDChlorpyrifos results in increased expression of RELA mRNA; Chlorpyrifos results in increased expression of RELA proteinPMID:38849050 PMID:39419344
Relaincreases phosphorylationEXP 6480464CTDChlorpyrifos results in increased phosphorylation of RELA proteinPMID:26215101
Relamultiple interactionsEXP 6480464CTD[Chlorpyrifos co-treated with Dimethoate] results in increased expression of RELA protein; [Chlorpyrifos co-treated with Lipopolysaccharides] results in increased phosphorylation of RELA protein; Chlorpyrifos affects the localization of and results in increased phosphorylation of RELA protein; Farnesol inhibits the reaction [Chlorpyrifos results in increased expression of RELA mRNA]; Farnesol inhibits the reaction [Chlorpyrifos results in increased expression of RELA protein]; Glycyrrhizic Acid inhibits the reaction [Chlorpyrifos results in increased phosphorylation of RELA protein]; Hydrogen inhibits the reaction [[Chlorpyrifos co-treated with Lipopolysaccharides] results in increased phosphorylation of RELA protein]PMID:26524701 PMID:30236991 PMID:38849050 PMID:39419344
Relaincreases expressionISORela (Mus musculus)6480464CTDChlorpyrifos results in increased expression of RELA mRNAPMID:37019170
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