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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rela
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:34202
Term: 2,2',4,4',5,5'-hexachlorobiphenyl
Definition: A hexachlorobiphenyl that has formula C12H4Cl6.
Chemical ID: MESH:C014024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relaincreases phosphorylationEXP 6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of RELA proteinPMID:24726520
Relamultiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of RELA protein]PMID:24726520
Relamultiple interactionsISORela (Mus musculus)6480464CTD[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with 2,4,5,2',5'-pentachlorobiphenyl] inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]; [2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]PMID:26141388
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