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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727793
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rdh10
Name: retinol dehydrogenase 10
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rdh10affects expressionEXP 6480464CTDTretinoin affects the expression of RDH10 mRNAPMID:22262565
Rdh10decreases expressionEXP 6480464CTDTretinoin results in decreased expression of RDH10 mRNAPMID:20488242
Rdh10increases chemical synthesisEXP 6480464CTDRDH10 protein results in increased chemical synthesis of TretinoinPMID:21138835
Rdh10decreases expressionISORDH10 (Homo sapiens)6480464CTDTretinoin results in decreased expression of RDH10 mRNAPMID:33167477
Rdh10increases expressionISORDH10 (Homo sapiens)6480464CTDTretinoin results in increased expression of RDH10 mRNAPMID:21934132
Rdh10multiple interactionsISORDH10 (Homo sapiens)6480464CTD[PPARG protein results in increased expression of RDH10 protein] which results in increased chemical synthesis of TretinoinPMID:16982809
Rdh10multiple interactionsISORdh10 (Mus musculus)6480464CTD[DHRS3 gene mutant form results in increased abundance of Tretinoin] which results in decreased expression of RDH10 mRNAPMID:24005908
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