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GENE - TERM ANNOTATION REPORT

RGD ID: 727781
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sdccag8
Name: SHH signaling and ciliogenesis regulator SDCCAG8
Acc ID: DOID:1312
Term: focal segmental glomerulosclerosis
Definition: A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.
Definition Source(s): MESH:D005923
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sdccag8 ISOSDCCAG8 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Focal segmental glomerulosclerosis | ClinVar Annotator: match by term: Glomerulosclerosis, focalPMID:25741868
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