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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71016
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp8b1
Name: cytochrome P450 family 8 subfamily B member 1
Acc ID: CHEBI:2677
Term: Augmentin
Definition: A mixture composed of amoxicillin trihydrate and potassium clavulanate; a broad-spectrum antibiotic. The potassium clavulanate component is particularly active against the clinically important plasmid-mediated beta-lactamases frequently responsible for transferred drug resistance to penicillins and cephalosporins.
Chemical ID: MESH:D019980
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp8b1decreases expressionISOCYP8B1 (Homo sapiens)6480464CTDAmoxicillin-Potassium Clavulanate Combination results in decreased expression of CYP8B1 mRNAPMID:34767876
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