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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70967
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp6
Name: caspase 6
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp6increases expressionISOCASP6 (Homo sapiens)6480464CTDCisplatin results in increased expression of CASP6 mRNAPMID:27392435
Casp6multiple interactionsISOCASP6 (Homo sapiens)6480464CTD[Cisplatin co-treated with jinfukang] results in increased expression of CASP6 mRNAPMID:27392435
Casp6multiple interactionsISOCasp6 (Mus musculus)6480464CTDPAK2 protein modified form promotes the reaction [Cisplatin results in increased activity of CASP6 protein]PMID:21499899
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