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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708446
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccr1
Name: C-C motif chemokine receptor 1
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccr1decreases expressionEXP 6480464CTDSimvastatin results in decreased expression of CCR1 mRNAPMID:16414398
Ccr1multiple interactionsISOCCR1 (Homo sapiens)6480464CTDMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]]; Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]PMID:16321392
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