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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708432
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Trib3
Name: tribbles pseudokinase 3
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Trib3increases expressionISOTRIB3 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of TRIB3 mRNA; Arsenic Trioxide results in increased expression of TRIB3 proteinPMID:24356939 PMID:26705709 PMID:27829220 PMID:32929351
Trib3increases expressionISOTrib3 (Mus musculus)6480464CTDArsenic Trioxide results in increased expression of TRIB3 mRNAPMID:23892647
Trib3multiple interactionsISOTRIB3 (Homo sapiens)6480464CTD[Tretinoin co-treated with Arsenic Trioxide] results in increased expression of TRIB3 protein; Fenofibrate inhibits the reaction [Arsenic Trioxide results in increased expression of TRIB3 mRNA]; Fenofibrate inhibits the reaction [Arsenic Trioxide results in increased expression of TRIB3 protein]; Pioglitazone inhibits the reaction [Arsenic Trioxide results in increased expression of TRIB3 mRNA]PMID:32929351
Trib3multiple interactionsISOTrib3 (Mus musculus)6480464CTDsalubrinal promotes the reaction [Arsenic Trioxide results in increased expression of TRIB3 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of TRIB3 mRNA]PMID:23892647
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