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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708428
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akr1c3
Name: aldo-keto reductase family 1, member C3
Acc ID: CHEBI:37454
Term: 9,10-phenanthroquinone
Definition: A phenanthrene that has formula C14H8O2.
Chemical ID: MESH:C005399
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1c3increases expressionISOAKR1C3 (Homo sapiens)6480464CTD9,10-phenanthrenequinone results in increased expression of AKR1C3 proteinPMID:29108775
Akr1c3increases metabolic processingISOAKR1C3 (Homo sapiens)6480464CTDAKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinonePMID:17950253 PMID:29108775
Akr1c3increases reductionISOAKR1C3 (Homo sapiens)6480464CTDAKR1C3 protein results in increased reduction of 9,10-phenanthrenequinonePMID:19442656 PMID:21851338 PMID:23261716
Akr1c3multiple interactionsISOAKR1C3 (Homo sapiens)6480464CTD[AKR1C3 protein results in increased reduction of 9,10-phenanthrenequinone] which results in increased abundance of Superoxides; AKR1C3 protein results in increased reduction of and affects the activity of 9,10-phenanthrenequinone; Indomethacin analog inhibits the reaction [AKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinone]; Indomethacin inhibits the reaction [AKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinone]; N-(4-chlorobenzoyl)melatonin inhibits the reaction [AKR1C3 protein results in increased metabolism of 9,10-phenanthrenequinone]PMID:17950253 PMID:19442656 PMID:21910479
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