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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708428
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akr1c3
Name: aldo-keto reductase family 1, member C3
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1c3increases expressionISOAKR1C3 (Homo sapiens)6480464CTDHydrogen Peroxide results in increased expression of AKR1C3 proteinPMID:22964423
Akr1c3increases response to substanceISOAKR1C3 (Homo sapiens)6480464CTDAKR1C3 mutant form results in increased susceptibility to Hydrogen PeroxidePMID:22964423
Akr1c3multiple interactionsISOAKR1C3 (Homo sapiens)6480464CTD7-hydroxycoumarin inhibits the reaction [AKR1C3 mutant form results in increased susceptibility to Hydrogen Peroxide]; [AKR1C3 protein results in increased reduction of and affects the activity of benzo(a)pyrene-3,6-quinone] which results in increased chemical synthesis of Hydrogen PeroxidePMID:21910479 PMID:22964423
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