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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708428
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akr1c3
Name: aldo-keto reductase family 1, member C3
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1c3increases expressionISOAKR1C3 (Homo sapiens)6480464CTDTretinoin results in increased expression of AKR1C3 mRNAPMID:23724009 PMID:33167477
Akr1c3multiple interactionsISOAKR1C3 (Homo sapiens)6480464CTD[Tretinoin results in decreased activity of AKR1C3 protein] which results in increased susceptibility to Daunorubicin; Tretinoin binds to and results in decreased activity of AKR1C3 protein; Tretinoin inhibits the reaction [[AKR1C3 protein results in increased metabolism of Daunorubicin] which results in increased abundance of daunorubicinol]; Tretinoin inhibits the reaction [AKR1C3 protein results in increased metabolism of Daunorubicin]PMID:32588086
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