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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708425
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Havcr1
Name: hepatitis A virus cellular receptor 1
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Havcr1affects expressionEXP 6480464CTDCyclosporine affects the expression of HAVCR1 mRNA; Cyclosporine affects the expression of HAVCR1 proteinPMID:24971338
Havcr1increases expressionEXP 6480464CTDCyclosporine results in increased expression of HAVCR1 mRNAPMID:21865292
Havcr1increases expressionISOHavcr1 (Mus musculus)6480464CTDCyclosporine results in increased expression of HAVCR1 mRNAPMID:23958496 PMID:27585667
Havcr1multiple interactionsISOHavcr1 (Mus musculus)6480464CTDethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Cyclosporine results in increased expression of HAVCR1 mRNA]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of HAVCR1 mRNA]PMID:27585667
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