Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	70500
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Mapk1
Name:	mitogen activated protein kinase 1

Acc ID:	CHEBI:32497
Term:	thioacetamide
Definition:	A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur.
Chemical ID:	MESH:D013853

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Mapk1	increases expression	EXP		6480464	CTD	Thioacetamide results in increased expression of MAPK1 protein	PMID:21251946
Mapk1	multiple interactions	EXP		6480464	CTD	[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of MAPK1 mRNA; Thioctic Acid inhibits the reaction [Thioacetamide results in increased expression of MAPK1 protein]	PMID:21251946 PMID:23830814
Mapk1	increases phosphorylation	ISO	Mapk1 (Mus musculus)	6480464	CTD	Thioacetamide results in increased phosphorylation of MAPK1 protein	PMID:20713078 PMID:31323263
Mapk1	multiple interactions	ISO	Mapk1 (Mus musculus)	6480464	CTD	Tadalafil inhibits the reaction [Thioacetamide results in increased phosphorylation of MAPK1 protein]; TXNIP gene mutant form inhibits the reaction [Thioacetamide results in increased phosphorylation of MAPK1 protein]	PMID:20713078 PMID:31323263

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