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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:31882
Term: N-methyl-D-aspartic acid
Definition: An aspartic acid derivative having an N-methyl substituent and D-configuration.
Chemical ID: MESH:D016202
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1increases expressionEXP 6480464CTDN-Methylaspartate results in increased expression of MAPK1 protein modified formPMID:22639866
Mapk1multiple interactionsEXP 6480464CTDthieno(2,3-c)isoquinolin-5-one inhibits the reaction [N-Methylaspartate results in increased expression of MAPK1 protein modified form]PMID:22639866
Mapk1decreases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDN-Methylaspartate results in decreased phosphorylation of MAPK1 proteinPMID:26065936
Mapk1increases phosphorylationISOMAPK1 (Homo sapiens)6480464CTDN-Methylaspartate results in increased phosphorylation of MAPK1 proteinPMID:35257817
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTDCAV1 protein affects the reaction [N-Methylaspartate results in increased phosphorylation of MAPK1 protein]; kukoamine B inhibits the reaction [N-Methylaspartate results in decreased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [N-Methylaspartate results in increased phosphorylation of MAPK1 protein]PMID:26065936 PMID:35257817
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