Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk1
Name: mitogen activated protein kinase 1
Acc ID: CHEBI:15940
Term: nicotinic acid
Definition: A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.
Chemical ID: MESH:D009525
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk1multiple interactionsISOMAPK1 (Homo sapiens)6480464CTD[Niacin binds to and results in increased activity of HCAR2 protein] which results in increased phosphorylation of MAPK1 protein; [Niacin binds to and results in increased activity of HCAR3 protein] which results in increased phosphorylation of MAPK1 protein; Pertussis Toxin inhibits the reaction [Niacin results in increased phosphorylation of MAPK1 protein]PMID:16389067
Go Back to source page   Continue to Ontology report