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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70495
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k1
Name: mitogen activated protein kinase kinase 1
Acc ID: CHEBI:15600
Term: (+)-catechin
Definition: The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.
Chemical ID: MESH:D002392
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k1decreases expressionISOMAP2K1 (Homo sapiens)6480464CTDCatechin results in decreased expression of MAP2K1 mRNA; Catechin results in decreased expression of MAP2K1 proteinPMID:15465739
Map2k1increases expressionISOMAP2K1 (Homo sapiens)6480464CTDCatechin results in increased expression of MAP2K1 mRNAPMID:15465739
Map2k1multiple interactionsISOMAP2K1 (Homo sapiens)6480464CTDCatechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of MAP2K1 protein]PMID:21882252
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