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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70487
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ctnnb1
Name: catenin beta 1
Acc ID: CHEBI:62878
Term: XAV939
Definition: A thiopyranopyrimidine in which a 7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine skeleton is substituted at C-4 by a hydroxy group and at C-2 by a para-(trifluoromethyl)phenyl group.
Chemical ID: MESH:C544261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctnnb1decreases expressionEXP 6480464CTDXAV939 results in decreased expression of CTNNB1 proteinPMID:24231000
Ctnnb1multiple interactionsEXP 6480464CTDXAV939 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CTNNB1 protein]PMID:24231000
Ctnnb1decreases expressionISOCtnnb1 (Mus musculus)6480464CTDXAV939 results in decreased expression of CTNNB1 mRNAPMID:27226553
Ctnnb1decreases expressionISOCTNNB1 (Homo sapiens)6480464CTDXAV939 results in decreased expression of CTNNB1 proteinPMID:25061499
Ctnnb1multiple interactionsISOCtnnb1 (Mus musculus)6480464CTDXAV939 inhibits the reaction [bavachin results in increased expression of CTNNB1 protein]PMID:37748667
Ctnnb1multiple interactionsISOCTNNB1 (Homo sapiens)6480464CTDXAV939 inhibits the reaction [bavachin results in increased expression of CTNNB1 protein]; XAV939 inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein]; XAV939 inhibits the reaction [KIF23 protein results in increased expression of CTNNB1 protein]; XAV939 inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein]; XAV939 inhibits the reaction [TMED3 protein results in increased expression of CTNNB1 protein]; XAV939 promotes the reaction [thymoquinone results in decreased expression of and results in increased phosphorylation of CTNNB1 protein]; XAV939 results in decreased expression of and results in increased phosphorylation of CTNNB1 proteinPMID:24534281 PMID:32112862 PMID:34758370 PMID:34933054 PMID:37748667
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