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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69407
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sik1
Name: salt-inducible kinase 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sik1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of SIK1 mRNAPMID:32109520
Sik1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of SIK1 mRNAPMID:33387578 PMID:34747641
Sik1affects expressionISOSIK1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of SIK1 mRNAPMID:22298810
Sik1affects expressionISOSik1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of SIK1 mRNAPMID:21570461 PMID:26377647
Sik1decreases expressionISOSik1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of SIK1 mRNAPMID:19933214 PMID:21354282 PMID:21889950 PMID:26290441
Sik1increases expressionISOSik1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of SIK1 mRNAPMID:25270620
Sik1multiple interactionsISOSik1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of SIK1 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of SIK1 mRNAPMID:25975270 PMID:28433925
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