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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
Acc ID: CHEBI:90695
Term: anthra[1,9-cd]pyrazol-6(2H)-one
Definition: A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.
Chemical ID: MESH:C432165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1amultiple interactionsEXP 6480464CTDpyrazolanthrone promotes the reaction [Diethylnitrosamine results in increased expression of CDKN1A protein]PMID:19418558
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDpyrazolanthrone results in increased expression of CDKN1A proteinPMID:16061660
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTDpyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of CDKN1A protein]; pyrazolanthrone inhibits the reaction [tributyltin results in increased expression of CDKN1A protein]; pyrazolanthrone promotes the reaction [Arsenic Trioxide results in increased expression of CDKN1A mRNA]; pyrazolanthrone promotes the reaction [Arsenic Trioxide results in increased expression of CDKN1A protein]; pyrazolanthrone promotes the reaction [EGF protein results in increased expression of CDKN1A mRNA]PMID:15961274 PMID:16283431 PMID:31734849 PMID:36319700
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