GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cdkn1a | decreases expression | EXP | | 6480464 | CTD | Copper results in decreased expression of CDKN1A mRNA | PMID:30556269 | Cdkn1a | increases expression | EXP | | 6480464 | CTD | Copper results in increased expression of CDKN1A mRNA | PMID:22465980 | Cdkn1a | multiple interactions | EXP | | 6480464 | CTD | [ATP7B protein affects the susceptibility to Copper] which affects the expression of CDKN1A mRNA | PMID:23112546 | Cdkn1a | increases expression | ISO | CDKN1A (Homo sapiens) | 6480464 | CTD | Copper results in increased expression of CDKN1A protein | PMID:15880691 | Cdkn1a | multiple interactions | ISO | CDKN1A (Homo sapiens) | 6480464 | CTD | [Chelating Agents binds to Copper] which results in increased expression of CDKN1A mRNA; [Chelating Agents binds to Copper] which results in increased expression of CDKN1A protein; [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of CDKN1A protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein; [Copper results in increased activity of TP53 protein] which results in increased expression of CDKN1A mRNA; [NSC 689534 binds to Copper] which results in increased expression of CDKN1A mRNA; Tretinoin inhibits the reaction [[Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein] | PMID:16391388 PMID:17327230 PMID:20971185 PMID:30911355 | | ||||||||||||||||||||||
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