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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69323
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Erbb3
Name: erb-b2 receptor tyrosine kinase 3
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Erbb3increases expressionEXP 6480464CTDAcetaminophen results in increased expression of ERBB3 mRNAPMID:33387578
Erbb3multiple interactionsEXP 6480464CTD[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of ERBB3 mRNAPMID:25607892
Erbb3decreases expressionISOERBB3 (Homo sapiens)6480464CTDAcetaminophen results in decreased expression of ERBB3 mRNAPMID:21420995
Erbb3decreases expressionISOErbb3 (Mus musculus)6480464CTDAcetaminophen results in decreased expression of ERBB3 mRNAPMID:29246445
Erbb3increases expressionISOErbb3 (Mus musculus)6480464CTDAcetaminophen results in increased expression of ERBB3 mRNAPMID:17585979
Erbb3multiple interactionsISOErbb3 (Mus musculus)6480464CTDPANX1 gene mutant form promotes the reaction [Acetaminophen results in decreased expression of ERBB3 mRNA]; YAP1 gene mutant form promotes the reaction [Acetaminophen results in increased expression of ERBB3 mRNA]PMID:29246445 PMID:34546377
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