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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Irs2
Name: insulin receptor substrate 2
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Irs2decreases expressionEXP 6480464CTDStreptozocin results in decreased expression of IRS2 mRNA; Streptozocin results in decreased expression of IRS2 proteinPMID:26071184 PMID:26286522 PMID:27417257 PMID:33724628
Irs2multiple interactionsEXP 6480464CTD[Streptozocin co-treated with Cadmium] results in decreased expression of IRS2 protein; [Streptozocin co-treated with Niacinamide] results in decreased expression of IRS2 protein; asiatic acid inhibits the reaction [Streptozocin results in decreased expression of IRS2 protein]; eupafolin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of IRS2 protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of IRS2 protein]; myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased expression of IRS2 protein]; myrtenal inhibits the reaction [Streptozocin results in decreased expression of IRS2 protein]; piperlongumine inhibits the reaction [Streptozocin results in decreased expression of IRS2 protein]; Quercetin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of IRS2 protein]; Resveratrol inhibits the reaction [Streptozocin results in decreased expression of IRS2 mRNA]PMID:24923654 PMID:26071184 PMID:26286522 PMID:27417257 PMID:33724628 PMID:37566541
Irs2multiple interactionsISOIrs2 (Mus musculus)6480464CTD[Streptozocin co-treated with bisphenol A] results in decreased expression of IRS2 mRNA; [Streptozocin co-treated with octylphenol] results in decreased expression of IRS2 mRNAPMID:29935216
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