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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69287
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sqstm1
Name: sequestosome 1
Acc ID: CHEBI:63918
Term: artesunate
Definition: An artemisinin derivative that is the hemisuccinate ester of the lactol resulting from the reduction of the lactone carbonyl group of artemisinin. It is used, generally as the sodium salt, for the treatment of malaria.
Chemical ID: MESH:C039726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sqstm1decreases expressionISOSQSTM1 (Homo sapiens)6480464CTDArtesunate results in decreased expression of SQSTM1 mRNA; Artesunate results in decreased expression of SQSTM1 proteinPMID:30551460
Sqstm1multiple interactionsISOSQSTM1 (Homo sapiens)6480464CTDChloroquine inhibits the reaction [Artesunate results in decreased expression of SQSTM1 protein]PMID:30551460
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