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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69287
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sqstm1
Name: sequestosome 1
Acc ID: CHEBI:6078
Term: ivermectin
Definition: A mixture consisting of >= 90% 22,23-dihydroavermectin B1a (R = Me) and <= 10% 22,23-dihydroavermectin B1b (R = H). A semi-synthetic derivative of abamectin, it is used as a broad-spectrum antiparasite medication, particularly against worms (except tapeworms), although it is also effective against most mites and some lice.
Chemical ID: MESH:D007559
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sqstm1decreases expressionISOSQSTM1 (Homo sapiens)6480464CTDIvermectin results in decreased expression of SQSTM1 proteinPMID:32959892 PMID:34904774
Sqstm1multiple interactionsISOSQSTM1 (Homo sapiens)6480464CTD3-methyladenine inhibits the reaction [Ivermectin results in decreased expression of SQSTM1 protein]; AZD 1480 inhibits the reaction [SLC2A4 protein inhibits the reaction [Ivermectin results in decreased expression of SQSTM1 protein]]; Glutathione inhibits the reaction [Ivermectin results in decreased expression of SQSTM1 protein]; SLC2A4 protein inhibits the reaction [Ivermectin results in decreased expression of SQSTM1 protein]PMID:34904774
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