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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdh1
Name: cadherin 1
Acc ID: CHEBI:46680
Term: serpentine asbestos
Definition: null
Chemical ID: MESH:D017632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdh1decreases expressionISOCDH1 (Homo sapiens)6480464CTDAsbestos, Serpentine results in decreased expression of CDH1 mRNA; Asbestos, Serpentine results in decreased expression of CDH1 proteinPMID:24160326 PMID:26685284 PMID:30609805
Cdh1multiple interactionsISOCDH1 (Homo sapiens)6480464CTD1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one analog inhibits the reaction [Asbestos, Serpentine results in decreased expression of CDH1 protein]; SB 216763 inhibits the reaction [Asbestos, Serpentine results in decreased expression of CDH1 protein]; TGFB1 protein affects the reaction [Asbestos, Serpentine results in decreased expression of CDH1 protein]PMID:26685284 PMID:30609805
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