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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69168
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARG
Name: peroxisome proliferator activated receptor gamma
Acc ID: CHEBI:34202
Term: 2,2',4,4',5,5'-hexachlorobiphenyl
Definition: A hexachlorobiphenyl that has formula C12H4Cl6.
Chemical ID: MESH:C014024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARGdecreases expressionISOPparg (Mus musculus)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of PPARG mRNA; 2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of PPARG proteinPMID:31449830
PPARGmultiple interactionsISOPparg (Mus musculus)6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] promotes the reaction [[Dietary Sucrose co-treated with Dietary Fats] results in decreased expression of PPARG mRNA]; [retinol acetate co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of PPARG mRNA; NR1I3 protein affects the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of PPARG mRNA]; NR1I3 protein affects the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of PPARG protein]; NR1I3 protein affects the reaction [[retinol acetate co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in increased expression of PPARG mRNA]PMID:30722647 PMID:31449830
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