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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69168
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARG
Name: peroxisome proliferator activated receptor gamma
Acc ID: CHEBI:132612
Term: monobenzyl phthalate
Definition: A phthalic acid monoester resulting from the formal condensation of one of the carboxy groups of phthalic acid with the hydroxy group of benzyl alcohol. It is a major metabolite of the plasticiser butyl benzyl phthalate (BBP).
Chemical ID: MESH:C103325
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARGaffects bindingEXP 6480464CTDmono-benzyl phthalate binds to PPARG proteinPMID:23843199
PPARGincreases activityEXP 6480464CTDmono-benzyl phthalate results in increased activity of PPARG proteinPMID:27551952
PPARGincreases expressionEXP 6480464CTDmono-benzyl phthalate results in increased expression of PPARG proteinPMID:29089286
PPARGmultiple interactionsISOPparg (Mus musculus)6480464CTD[monoethyl phthalate co-treated with mono-(2-ethylhexyl)phthalate co-treated with mono-isobutyl phthalate co-treated with monoisononylphthalate co-treated with mono-benzyl phthalate] results in increased expression of PPARG mRNAPMID:31884101
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