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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69105
Species: Homo sapiens
RGD Object: Gene
Symbol: NR1I2
Name: nuclear receptor subfamily 1 group I member 2
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR1I2affects localizationEXP 6480464CTDochratoxin A affects the localization of NR1I2 proteinPMID:30291945
NR1I2decreases expressionEXP 6480464CTDochratoxin A analog results in decreased expression of NR1I2 protein; ochratoxin A results in decreased expression of NR1I2 mRNA; ochratoxin A results in decreased expression of NR1I2 proteinPMID:26341324 PMID:32659470
NR1I2increases expressionEXP 6480464CTDochratoxin A results in increased expression of NR1I2 mRNAPMID:30291945
NR1I2multiple interactionsEXP 6480464CTDDactinomycin inhibits the reaction [ochratoxin A results in decreased expression of NR1I2 mRNA]; NR1I2 protein affects the reaction [ochratoxin A results in increased expression of GCLC mRNA]; NR1I2 protein affects the reaction [ochratoxin A results in increased expression of HAVCR1 mRNA]; NR1I2 protein affects the reaction [ochratoxin A results in increased expression of HMOX1 mRNA]; NR1I2 protein affects the reaction [ochratoxin A results in increased expression of NFE2L2 mRNA]; ochratoxin A inhibits the reaction [Rifampin results in increased activity of NR1I2 protein]PMID:26341324 PMID:30291945
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