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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69096
Species: Mus musculus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:18145
Term: (R,R,R)-alpha-tocopherol
Definition: An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.
Chemical ID: MESH:D024502
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1decreases expressionISOTgfb1 (Rattus norvegicus)6480464CTDalpha-Tocopherol results in decreased expression of TGFB1 mRNAPMID:9608545
Tgfb1multiple interactionsISOTgfb1 (Rattus norvegicus)6480464CTDalpha-Tocopherol inhibits the reaction [Acrylamide results in increased expression of TGFB1 protein]; alpha-Tocopherol inhibits the reaction [TGFB1 protein results in increased abundance of Reactive Oxygen Species]PMID:14732287 PMID:38242491
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