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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69079
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Wnt7a
Name: Wnt family member 7A
Acc ID: CHEBI:41922
Term: diethylstilbestrol
Definition: An olefinic compound that is trans-hex-3-ene in which the hydrogens at positions 3 and 4 have been replaced by p-hydroxyphenyl groups.
Chemical ID: MESH:D004054
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Wnt7adecreases expressionISOWNT7A (Homo sapiens)6480464CTDDiethylstilbestrol results in decreased expression of WNT7A mRNAPMID:16534752
Wnt7adecreases expressionISOWnt7a (Mus musculus)6480464CTDDiethylstilbestrol results in decreased expression of WNT7A mRNAPMID:15070830 PMID:15458790 PMID:15591538 PMID:15751030
Wnt7aincreases response to substanceISOWnt7a (Mus musculus)6480464CTDWNT7A gene mutant form results in increased susceptibility to DiethylstilbestrolPMID:15070830
Wnt7amultiple interactionsISOWnt7a (Mus musculus)6480464CTDESR1 protein affects the reaction [Diethylstilbestrol results in decreased expression of WNT7A mRNA]; WNT5A protein affects the reaction [Diethylstilbestrol results in decreased expression of WNT7A mRNA]; WNT7A protein affects the reaction [Diethylstilbestrol results in decreased expression of HOXA10 mRNA]; WNT7A protein affects the reaction [Diethylstilbestrol results in decreased expression of HOXA11 mRNA]PMID:15070830 PMID:15073149 PMID:15458790
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