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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:5864
Term: ifosfamide
Definition: The simplest member of the class of ifosfamides that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by 2-chloroethyl groups on both the nitrogen atoms respectively. It is a nitrogen mustard alkylating agent used in the treatment of advanced breast cancer.
Chemical ID: MESH:D007069
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2increases activityISONR1I2 (Homo sapiens)6480464CTDIfosfamide results in increased activity of NR1I2 proteinPMID:20041327
Nr1i2multiple interactionsISONR1I2 (Homo sapiens)6480464CTD[Ifosfamide results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; Ifosfamide binds to and results in increased activity of NR1I2 protein; NR1I2 protein promotes the reaction [Ifosfamide results in increased expression of ABCB1 protein]PMID:18839173 PMID:20041327
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