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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69022
Species: Homo sapiens
RGD Object: Gene
Symbol: FDPS
Name: farnesyl diphosphate synthase
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FDPSaffects expressionEXP 6480464CTDValproic Acid affects the expression of FDPS mRNAPMID:25979313
FDPSdecreases expressionEXP 6480464CTDValproic Acid results in decreased expression of FDPS mRNAPMID:23179753 PMID:27188386 PMID:29154799
FDPSdecreases methylationEXP 6480464CTDValproic Acid results in decreased methylation of FDPS genePMID:29154799
FDPSmultiple interactionsEXP 6480464CTD[Hydralazine co-treated with Valproic Acid] results in increased expression of FDPS mRNAPMID:17183730
FDPSaffects expressionISOFdps (Mus musculus)6480464CTDValproic Acid affects the expression of FDPS mRNAPMID:17292431 PMID:17963808
FDPSaffects splicingISOFdps (Rattus norvegicus)6480464CTDValproic Acid affects the splicing of FDPS mRNAPMID:29427782
FDPSdecreases expressionISOFdps (Mus musculus)6480464CTDValproic Acid results in decreased expression of FDPS mRNAPMID:22045034
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