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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69014
Species: Homo sapiens
RGD Object: Gene
Symbol: SERPINE1
Name: serpin family E member 1
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SERPINE1increases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in increased expression of SERPINE1 mRNAPMID:33772556
SERPINE1affects expressionISOSerpine1 (Mus musculus)6480464CTDperfluorooctane sulfonic acid affects the expression of SERPINE1 mRNAPMID:19429403
SERPINE1increases expressionISOSerpine1 (Mus musculus)6480464CTDperfluorooctane sulfonic acid results in increased expression of SERPINE1 mRNAPMID:20936131
SERPINE1multiple interactionsISOSerpine1 (Mus musculus)6480464CTD[perfluorooctane sulfonic acid co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of SERPINE1 mRNA; [perfluorooctane sulfonic acid co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of SERPINE1 protein; [perfluorooctane sulfonic acid co-treated with Pectins] results in increased expression of SERPINE1 mRNAPMID:33096110 PMID:36331819
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