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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68660
Species: Mus musculus
RGD Object: Gene
Symbol: Bhlhe40
Name: basic helix-loop-helix family, member e40
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bhlhe40affects methylationEXP 6480464CTDbisphenol A affects the methylation of BHLHE40 promoterPMID:27334623
Bhlhe40increases expressionEXP 6480464CTDbisphenol A results in increased expression of BHLHE40 mRNAPMID:25270620
Bhlhe40affects expressionISOBhlhe40 (Rattus norvegicus)6480464CTDbisphenol A affects the expression of BHLHE40 mRNAPMID:32145629
Bhlhe40decreases expressionISOBHLHE40 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of BHLHE40 mRNAPMID:16474171
Bhlhe40increases expressionISOBhlhe40 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of BHLHE40 mRNAPMID:25181051
Bhlhe40increases expressionISOBHLHE40 (Homo sapiens)6480464CTDbisphenol A results in increased expression of BHLHE40 mRNAPMID:29275510
Bhlhe40multiple interactionsISOBHLHE40 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BHLHE40 mRNAPMID:28628672
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