GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Dio2 | increases expression | EXP | | 6480464 | CTD | 2,2',4,4'-tetrabromodiphenyl ether results in increased expression of DIO2 mRNA | PMID:27420076 | Dio2 | multiple interactions | EXP | | 6480464 | CTD | 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [Thyroxine results in decreased expression of DIO2 mRNA] | PMID:27420076 | Dio2 | decreases expression | ISO | DIO2 (Homo sapiens) | 6480464 | CTD | 2,2',4,4'-tetrabromodiphenyl ether metabolite results in decreased expression of DIO2 mRNA | PMID:26004626 | Dio2 | multiple interactions | ISO | DIO2 (Homo sapiens) | 6480464 | CTD | 2,2',4,4'-tetrabromodiphenyl ether metabolite inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]; 2,2',4,4'-tetrabromodiphenyl ether metabolite results in decreased activity of and results in increased degradation of DIO2 protein | PMID:26004626 | | ||||||||||||||||||||||
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