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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68620
Species: Mus musculus
RGD Object: Gene
Symbol: Dio2
Name: deiodinase, iodothyronine, type II
Acc ID: CHEBI:42588
Term: 4-hydroxyphenyl retinamide
Definition: A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.
Chemical ID: MESH:D017313
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dio2increases expressionEXP 6480464CTDFenretinide results in increased expression of DIO2 mRNAPMID:28973697
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