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ONTOLOGY REPORT - ANNOTATIONS


Term:4-hydroxyphenyl retinamide
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Accession:CHEBI:42588 term browser browse the term
Definition:A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.
Synonyms:exact_synonym: 15-[(4-hydroxyphenyl)amino]retinal
 related_synonym: 4-HPR;   4-hydroxy(phenyl)retinamide;   Formula=C26H33NO2;   InChI=1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24,4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28H,7,10,17H2,1-5H3,(H,27,29)/b9-6+,16-11+,19-8+,20-18+;   InChIKey=AKJHMTWEGVYYSE-FXILSDISSA-N;   N-(4-Hydroxyphenyl)retinamide;   N-(4-hydroxyphenyl)all-trans retinamide;   SMILES=CC(\\C=C\\C1=C(C)CCCC1(C)C)=C/C=C/C(C)=C/C(=O)Nc1ccc(O)cc1;   all-trans-4'-Hydroxyretinanilide;   fenretinida;   fenretinide;   fenretinidum
 xref: CAS:65646-68-6;   DrugBank:DB05076;   KEGG:D04162
 xref_mesh: MESH:D017313
 xref: PDBeChem:FEN;   PMID:20878269;   PMID:20978709;   PMID:21241664;   PMID:21319187;   PMID:21674264;   PMID:21964808;   PMID:22094120;   PMID:22162577;   PMID:22183330;   PMID:22221098;   PMID:22280430;   PMID:22323082;   PMID:22350416;   PMID:22382323;   PMID:22387538;   Reaxys:5769490


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Term Annotations click to browse term
  CHEBI ontology 21260
    role 21244
      chemical role 20598
        antioxidant 14321
          4-hydroxyphenyl retinamide 4100
Path 2
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  CHEBI ontology 21260
    subatomic particle 21256
      composite particle 21256
        hadron 21256
          baryon 21256
            nucleon 21256
              atomic nucleus 21256
                atom 21256
                  main group element atom 21122
                    p-block element atom 21122
                      carbon group element atom 20893
                        carbon atom 20784
                          organic molecular entity 20784
                            organic group 19177
                              organic divalent group 19167
                                organodiyl group 19167
                                  carbonyl group 19137
                                    carbonyl compound 19137
                                      carboxylic acid 18818
                                        carboacyl group 17470
                                          univalent carboacyl group 17470
                                            carbamoyl group 17163
                                              carboxamide 17163
                                                monocarboxylic acid amide 14466
                                                  4-hydroxyphenyl retinamide 4100
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