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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68533
Species: Homo sapiens
RGD Object: Gene
Symbol: MTOR
Name: mechanistic target of rapamycin kinase
Acc ID: CHEBI:34440
Term: 4-nonylphenol
Definition: A member of the class of phenols that is phenol which is para-substituted with a nonyl group.
Chemical ID: MESH:C041594
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MTORdecreases phosphorylationISOMtor (Rattus norvegicus)6480464CTD4-nonylphenol results in decreased phosphorylation of MTOR proteinPMID:26804764 PMID:28041982
MTORincreases phosphorylationISOMtor (Rattus norvegicus)6480464CTD4-nonylphenol results in increased phosphorylation of MTOR proteinPMID:30228064
MTORmultiple interactionsISOMtor (Rattus norvegicus)6480464CTD4-nonylphenol inhibits the reaction [bisphenol A results in decreased expression of MTOR mRNA]; 4-nonylphenol inhibits the reaction [bisphenol A results in increased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]; AICA ribonucleotide promotes the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]; bisphenol A inhibits the reaction [4-nonylphenol results in increased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]; PRKAA1 protein promotes the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]PMID:26804764 PMID:28041982 PMID:30228064
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