Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	68515
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	LRAT
Name:	lecithin retinol acyltransferase

Acc ID:	CHEBI:15367
Term:	all-trans-retinoic acid
Definition:	A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID:	MESH:D014212

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
LRAT	decreases expression	EXP		6480464	CTD	Tretinoin results in decreased expression of LRAT mRNA	PMID:21934132
LRAT	increases expression	EXP		6480464	CTD	Tretinoin results in increased expression of LRAT protein	PMID:15982314
LRAT	increases expression	ISO	Lrat (Rattus norvegicus)	6480464	CTD	Tretinoin results in increased expression of LRAT mRNA	PMID:21138835
LRAT	increases expression	ISO	Lrat (Mus musculus)	6480464	CTD	Tretinoin results in increased expression of LRAT mRNA	PMID:36189433
LRAT	multiple interactions	ISO	Lrat (Rattus norvegicus)	6480464	CTD	[Tetrachlorodibenzodioxin results in increased activity of LRAT protein] which results in increased chemical synthesis of Tretinoin	PMID:11097864
LRAT	multiple interactions	ISO	Lrat (Mus musculus)	6480464	CTD	[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of LRAT mRNA	PMID:36189433

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