GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Aqp9 | affects expression | ISO | AQP9 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide affects the expression of AQP9 protein | PMID:19100828 | Aqp9 | increases expression | ISO | AQP9 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased expression of AQP9 protein | PMID:21945491 | Aqp9 | increases import | ISO | AQP9 (Homo sapiens) | 6480464 | CTD | AQP9 protein results in increased import of Arsenic Trioxide | PMID:16968895 | Aqp9 | increases response to substance | ISO | AQP9 (Homo sapiens) | 6480464 | CTD | AQP9 protein results in increased susceptibility to Arsenic Trioxide | PMID:16968895 | Aqp9 | increases uptake | ISO | AQP9 (Homo sapiens) | 6480464 | CTD | AQP9 protein results in increased uptake of Arsenic Trioxide | PMID:19100828 PMID:35590355 | Aqp9 | multiple interactions | ISO | AQP9 (Homo sapiens) | 6480464 | CTD | [Azacitidine results in increased expression of AQP9 mRNA] which results in increased uptake of Arsenic Trioxide; [CSF3 protein results in increased expression of AQP9 mRNA] which results in increased uptake of Arsenic Trioxide; [CSF3 protein results in increased expression of AQP9 protein] which results in increased uptake of Arsenic Trioxide; [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of AQP9 mRNA; [Tretinoin results in increased expression of AQP9 mRNA] which results in increased import of Arsenic Trioxide; [Tretinoin results in increased expression of AQP9 mRNA] which results in increased susceptibility to Arsenic Trioxide; AQP9 protein affects the reaction [Arsenic Trioxide promotes the reaction [Tretinoin results in decreased expression of and results in increased degradation of PIN1 protein]]; AQP9 protein affects the reaction [PIN1 protein affects the susceptibility to Arsenic Trioxide]; AQP9 protein affects the reaction [Tretinoin promotes the reaction [Arsenic Trioxide results in decreased expression of and results in increased degradation of PIN1 protein]]; AQP9 protein affects the uptake of and affects the susceptibility to Arsenic Trioxide; AQP9 protein promotes the reaction [CSF3 protein results in increased uptake of Arsenic Trioxide]; AQP9 protein results in increased uptake of and results in increased susceptibility to Arsenic Trioxide | PMID:15336539 PMID:16968895 PMID:19225113 PMID:23563754 PMID:25953102 PMID:30093655 PMID:35590355 | | ||||||||||||||||||||||
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