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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68407
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lrp2
Name: LDL receptor related protein 2
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lrp2increases phosphorylationISOLrp2 (Mus musculus)6480464CTDCisplatin results in increased phosphorylation of LRP2 proteinPMID:22006019
Lrp2multiple interactionsISOLrp2 (Mus musculus)6480464CTD[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of LRP2 mRNAPMID:23625948
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