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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68350
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr5a1
Name: nuclear receptor subfamily 5, group A, member 1
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr5a1decreases expressionEXP 6480464CTDDiethylhexyl Phthalate results in decreased expression of NR5A1 mRNAPMID:16690193
Nr5a1decreases expressionISONr5a1 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in decreased expression of NR5A1 mRNA; Diethylhexyl Phthalate results in decreased expression of NR5A1 proteinPMID:31175881 PMID:34319233 PMID:35259346
Nr5a1decreases methylationISONr5a1 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in decreased methylation of NR5A1 genePMID:34319233
Nr5a1increases expressionISONr5a1 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased expression of NR5A1 mRNAPMID:37812459
Nr5a1increases methylationISONr5a1 (Mus musculus)6480464CTDDiethylhexyl Phthalate results in increased methylation of NR5A1 genePMID:34319233
Nr5a1multiple interactionsISONr5a1 (Mus musculus)6480464CTDicariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NR5A1 mRNA]; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NR5A1 protein]PMID:31175881 PMID:35259346
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