Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68335
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Por
Name: cytochrome p450 oxidoreductase
Acc ID: CHEBI:73755
Term: 1,2-dimethylhydrazine
Definition: A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Chemical ID: MESH:D019813
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Porincreases activityEXP 6480464CTD1,2-Dimethylhydrazine results in increased activity of POR proteinPMID:19497424 PMID:29108773
Pormultiple interactionsEXP 6480464CTDasiatic acid inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of POR protein]; hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of POR protein]PMID:19497424 PMID:29108773
Pordecreases expressionISOPor (Mus musculus)6480464CTD1,2-Dimethylhydrazine results in decreased expression of POR mRNAPMID:22206623
Pormultiple interactionsISOPor (Mus musculus)6480464CTD[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of POR mRNAPMID:22206623
Go Back to source page   Continue to Ontology report