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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631435
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Orc1
Name: origin recognition complex, subunit 1
Acc ID: CHEBI:63618
Term: pravastatin
Definition: A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.
Chemical ID: MESH:D017035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Orc1decreases expressionEXP 6480464CTDPravastatin results in decreased expression of ORC1 mRNAPMID:27225895
Orc1affects expressionISOOrc1 (Mus musculus)6480464CTDPravastatin affects the expression of ORC1 mRNAPMID:27225895
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