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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631434
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bbc3
Name: Bcl-2 binding component 3
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bbc3affects localizationISOBBC3 (Homo sapiens)6480464CTDSimvastatin affects the localization of BBC3 proteinPMID:20045437
Bbc3increases expressionISOBBC3 (Homo sapiens)6480464CTDSimvastatin results in increased expression of BBC3 mRNA; Simvastatin results in increased expression of BBC3 proteinPMID:17428261 PMID:20045437 PMID:21199873 PMID:37956312
Bbc3multiple interactionsISOBBC3 (Homo sapiens)6480464CTDMevalonic Acid inhibits the reaction [Simvastatin results in increased expression of BBC3 protein]; pifithrin inhibits the reaction [Simvastatin results in increased expression of BBC3 mRNA]; pifithrin inhibits the reaction [Simvastatin results in increased expression of BBC3 protein]PMID:20045437
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