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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631352
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tlr9
Name: toll-like receptor 9
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tlr9affects expressionISOTlr9 (Mus musculus)6480464CTDAcetaminophen affects the expression of TLR9 mRNAPMID:17562736
Tlr9increases response to substanceISOTlr9 (Mus musculus)6480464CTDTLR9 protein results in increased susceptibility to AcetaminophenPMID:19164858
Tlr9multiple interactionsISOTlr9 (Mus musculus)6480464CTDTLR9 protein affects the reaction [Acetaminophen results in increased expression of IL1B mRNA]PMID:19164858
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